Sep 28, - Different types of infections may cause itching or an abnormal discharge in the vagina. Abnormal discharge means abnormal color (brown. Jump to What causes vaginal itching, burning, and irritation? - Chlamydia, genital herpes, genital warts, trichomoniasis, gonorrhea and other organisms can cause vaginal/vulvar itching and irritation and other symptoms. Yeast infection (vaginal candidiasis).